D-penicillamine causes free radical-dependent inactivation of activator protein-1 DNA binding.

doi:10.1016/s0026-895x(25)09299-5

Paper

D-penicillamine causes free radical-dependent inactivation of activator protein-1 DNA binding.

Published Sep 1, 1996 · Malcolm L. Handel, Colin Watts, S. Sivertsen

Molecular pharmacology

Q1 SJR score

16

Citations

2

Influential Citations

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Abstract

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In Vitro Study

Study Snapshot

D-penicillamine inhibits AP-1 DNA binding by creating sulfur-containing radicals, targeting cysteine residues in Jun and Fos DNA binding domains.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

D-penicillamine causes free radical-dependent inactivation of activator protein-1 DNA binding.

References

Citations