[Antiarrhythmic drug allapinin: review of results of clinical investigation].

Paper

[Antiarrhythmic drug allapinin: review of results of clinical investigation].

Published 2002 · Sokolov Sf, Dzhakhangirov Fn

Kardiologiia

UNKNOWN SJR score

5

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0

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Abstract

Antiarrhythmic drug allapinin has been used in clinical practice for a long time but data of investigation of its effects and mechanism of action are scanty. The aim of this review is to summarize results of clinical studies of allapinin supplementing them with personal unpublished data. The review embraces pharmacokinetics and pharmacodynamics of the drug, its efficacy in the treatment of various cardiac rhythm disturbances and side effects. The conclusion is made that clinical application of allapinin as class 1C antiarrhythmic drug according to Vaughan-Williams classification should be guided by general recommendations concerning indications and contraindications for this class of antiarrhythmic drugs. Special feature of allapinin is its high efficacy for prevention of attacks of paroxysmal atrial fibrillation.

Literature Review

Study Snapshot

Allapinin is a highly effective class 1C antiarrhythmic drug with high efficacy in preventing attacks of paroxysmal atrial fibrillation, following general recommendations for this class of drugs.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

[Antiarrhythmic drug allapinin: review of results of clinical investigation].

References

Citations

Clinical Aspects of Aconitum Preparations

Aconite preparations have potential therapeutic uses in treating pain, rheumatism, and lethargy, but their use in Europe and the United States declined due to toxicity concerns.

Sodium-channel blockers might contribute to the prevention of ventricular tachycardia in patients with long QT syndrome type 2: a description of 4 cases.

Sodium-channel blockers may help prevent ventricular tachycardia in patients with long QT syndrome type 2, potentially reducing syncope episodes.

Solification with Hydrobromic Acid as a Factor Defining the Antiarrhythmic Effect of Lappaconitine Derivatives

Lappaconitine derivatives with hydrobromide show the highest antiarrhythmic activity, with no other base or salts showing this effect.

Oxidative Transformations of Lappaconitine and 19-Oxolappaconine, Structural Revision of an obtained 8,9-Seco Product

The oxidative transformation of 19-oxolappaconine with K2Cr2O7/30% H2SO4 in methylene chloride produces 10,12-dihydro-8,9-seco-19-oxolappaconine, a structural revision of the compound previously proposed.

Aconitum Alkaloids and Biological Activities

Aconitum alkaloids show analgesic, antiarrhythmic, and anticancer effects, with diester diterpenoid alkaloids being the most toxic and affecting sodium channels.