Drug-Induced Megaloblastic Anemia.

doi:10.1056/NEJMra1508861

Paper

Drug-Induced Megaloblastic Anemia.

Published Oct 21, 2015 · C. Hesdorffer, D. Longo

The New England journal of medicine

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Abstract

Many common drugs induce megaloblastic anemia by interfering with folate or vitamin B12 absorption, altering B12 metabolism, or blocking pathways in which these vitamins play a role. Supplements to overcome these effects or discontinuation of the drug may be necessary.

Study Snapshot

Key takeawayDrugs like antacids, antidepressants, and antipsychotics can cause megaloblastic anemia by interfering with folate or vitamin B12 absorption.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Drug-Induced Megaloblastic Anemia.

References

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