Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles

doi:10.1016/S0028-3908(98)00233-0

Paper

Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles

Published Jun 15, 1999 · O. Terland, T. Flatmark

Neuropharmacology

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55

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Abstract

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In Vitro Study

Study Snapshot

Cinnarizine and flunarizine inhibit proton pumping and catecholamine uptake in storage vesicles, potentially contributing to drug-induced parkinsonism as a side-effect.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Drug-induced parkinsonism: cinnarizine and flunarizine are potent uncouplers of the vacuolar H+-ATPase in catecholamine storage vesicles

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