Paper
An eco-friendly catalytic route for one-pot synthesis of 2-amino-6-(2-oxo-2Hchromen-3-yl)-4-arylnicotinonitrile derivatives by silica-supported perchloric acid (HClO4–SiO2) under solvent-free conditions
Published Mar 1, 2014 · M. Ghashang, K. Aswin, S. S. Mansoor
Research on Chemical Intermediates
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Abstract
A facile and environmentally benign synthesis of some 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-arylnicotinonitrile derivatives from the reaction of 3-acetylcoumarin, aromatic aldehydes, and malononitrile under solvent-free condition in the presence of silica-supported perchloric acid (HClO4–SiO2) is described. The ability to reuse the catalyst, the high yields, and ease of purification are the important features of this process.
This eco-friendly one-pot synthesis of 2-amino-6-(2-oxo-2H-chromen-3-yl)-4-arylnicotinonitrile derivatives using silica-supported perchloric acid under solvent-free conditions provides high yields and ease of purification.
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