The effect of 2-aminobutan-1-ols on the growth of the housefly (Musca domestica).

doi:10.1016/0010-406X(68)90348-4

Paper

The effect of 2-aminobutan-1-ols on the growth of the housefly (Musca domestica).

Published May 1, 1968 · R. Bridges, J. Ricketts

Comparative biochemistry and physiology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

2-aminobutan-1-ol retards housefly larvae growth, but choline effectively reverses this retardation at lower concentrations.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

The effect of 2-aminobutan-1-ols on the growth of the housefly (Musca domestica).

References

The incorporation, in vivo, of aminoalcohols into the phospholipids of the larva of the housefly, Musca domestica.

Aminoalcohols in housefly larvae's diets can cause growth retardation, but when combined with choline, growth returns to normal and development to adults continues.

THE FORMATION OF PHOSPHOLIPIDS CONTAINING UNNATURAL BASES BY THE CYTIDINE PATHWAY

Unnatural bases can be incorporated into tissue phospholipids in vivo, indicating a lack of specificity in enzymes responsible for phospholipid biosynthesis and their ability to function in vivo.

The conjugation of phenols with phosphate in grass grubs and flies.

Monoaryl phosphates and beta-glucosides of phenols are present in grass grubs and flies after exposure to phenols, suggesting a potential role in phenol-based insecticides.

The effect of 2-amino-2-methylpropanol on rat-liver mitochondria.

2-amino-2-methylpropanol prevents uncoupling in rat liver mitochondria during a choline-deficient diet, and also inhibits choline oxidation and phosphorylation.

THE REPLACEMENT OF LIPID-BOUND CHOLINE BY OTHER BASES IN THE PHOSPHOLIPIDS OF THE HOUSEFLY, MUSCA DOMESTICA.

Houseflies replace choline in their phospholipids with -methylcholine when fed acetyl--methylcholine or carnitine, but adults cannot decarboxylate carnitine, and phosphatidylcholine levels in their heads decrease when choline

Inhibition of de novo choline biosynthesis by 2-amino-2-methyl-1-propanol.

Chronic administration of 2-amino-2-methyl-1-propanol to young rats inhibits de novo choline synthesis, with a maximal effect after 5-6 days, but no acute effect in vivo.

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