The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. II. Dimethyl substitution accelerates pyrrole formation and protein crosslinking.

doi:10.1016/0041-008X(83)90024-8

Paper

The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. II. Dimethyl substitution accelerates pyrrole formation and protein crosslinking.

Published Dec 1, 1983 · D. Anthony, K. Boekelheide, C. Anderson

Toxicology and applied pharmacology

Q2 SJR score

87

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1

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Abstract

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In Vitro Study

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Study Snapshot

3,4-dimethyl-2,5-hexanedione, 20-30 times more potent than 2,5-hexanedione, accelerates pyrrole formation and protein crosslinking, potentially explaining neurofilament accumulation in neuropathies.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

The effect of 3,4-dimethyl substitution on the neurotoxicity of 2,5-hexanedione. II. Dimethyl substitution accelerates pyrrole formation and protein crosslinking.

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