Paper
The effect of 3-methyl substitution on the carcinogenicity of nitroso-4-piperidone.
Published Oct 1, 1984 · G. Singer, M. D. Reuber, M. Mangino
Carcinogenesis
Q1 SJR score
1
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0
Influential Citations
Abstract
The carcinogenic activity of the 3-methyl derivative of nitroso-4-piperidone was compared with that of the compound without the methyl group, by chronic administration to rats at equimolar doses in drinking water. Nitrosopiperidone induced both liver and esophageal tumors, whereas the 3-methyl derivative induced only tumors of the esophagus in a much shorter time.
Non-RCT
Animal StudyStudy Snapshot
The 3-methyl derivative of nitroso-4-piperidone is more carcinogenic to the esophageal mucosa than the unmethylated compound, with shorter tumor induction time.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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