Protective effect of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid, on dextran sulfate sodium-induced rat colitis.

doi:10.1055/s-0028-1088390

Paper

Protective effect of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid, on dextran sulfate sodium-induced rat colitis.

Published Feb 1, 2009 ·

Planta medica

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31

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Abstract

In the present study, we evaluated the effect of 4-methoxy-5-hydroxycanthin-6-one (CAN), a natural alkaloid isolated from Picrasma quassioides (D.Don) Benn., on ulcerative colitis induced by dextran sulfate sodium (DSS) in rats in comparison with the positive control drug, sulfasalazine (SASP). Given orally for several days, CAN significantly reduced the severity of colitis and mitigated changes in colon length, colon mucosa myeloperoxidase (MPO) activity, and the level of tumor necrosis factor-alpha (TNF-alpha) in serum. The effect of CAN was similar to that of SASP. These results suggest that CAN treatment might be an effective therapeutic intervention against ulcerative colitis induced by DSS.

Non-RCT

Animal Study

Study Snapshot

4-methoxy-5-hydroxycanthin-6-one (CAN) treatment effectively reduces the severity of ulcerative colitis induced by dextran sulfate sodium in rats, suggesting it as a potential therapeutic intervention.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Protective effect of 4-methoxy-5-hydroxycanthin-6-one, a natural alkaloid, on dextran sulfate sodium-induced rat colitis.

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References

Citations

β-carboline alkaloids in Picrasma quassioides and their chemotaxonomic significance

Picrasma quassioide is a valuable source of -carboline alkaloids with chemotaxonomic significance, which can serve as valuable markers for identifying the species and its related plants.

Alkaloids from Picrasma quassioides: An overview of their NMR data, biosynthetic pathways and pharmacological effects.

Alkaloids from Picrasma quassioides show anti-inflammatory, anticancer, and anti-viral effects on the cardiovascular system, with 127 compounds identified.

Natural-derived alkaloids exhibit great potential in the treatment of ulcerative colitis.

Natural-derived alkaloids show potential in treating ulcerative colitis due to their effectiveness and safety in modulating oxidative stress, immune response, intestinal flora, and improving gut barrier function.

Pharmacological effects of Picrasma quassioides (D. Don) Benn for inflammation, cancer and neuroprotection (Review)

P. quassioides extracts show potential in anti-inflammatory, anticancer, and neuroprotectant therapies due to their complex composition and pharmacological activities.

5-Hydroxy-4-methoxycanthin-6-one alleviates dextran sodium sulfate-induced colitis in rats via regulation of metabolic profiling and suppression of NF-κB/p65 signaling pathway.

PQ-A treatment protects rats against DSS-induced colitis by suppressing the NF-B/p65 signaling pathway, regulating metabolic pathways and reducing inflammation.

Pharmacokinetic and bioavailability study of 5-hydroxy-4-methoxycanthin-6-one, a typical canthinone alkaloid, in rats by ultra-high performance liquid chromatography/electrospray ionization tandem mass spectrometry.

5-Hydroxy-4-methoxycanthin-6-one is rapidly absorbed into blood and has a moderate elimination half-life, but low bioavailability after oral administration.

Mucus-penetrating polymeric nanoparticles for oral delivery of curcumin to inflamed colon tissue

PF127-functionalized polymeric nanoparticles with curcumin show promising and efficient oral delivery to inflamed colon tissue, potentially improving ulcerative colitis therapy.

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease

Plant-derived alkaloids show potential in treating inflammatory bowel disease by improving colonic oxidative and pro-inflammatory status, preserving epithelial barrier function, and modulating gut microbiota.