Chronic hypoxia induced by the oral ingestion of nitrites yielded significant reductions in the tumor incidence of animals exposed to the minimal carcinogenic dose 50 of methylcholanthrene. Sodium cobaltinitrite was a more effective antitumorigenic agent than sodium nitrite, although both agents produced comparable methemoglobin levels.

Chronic oral administration of sodium cobaltinitrite significantly reduces tumor incidence in mice exposed to the minimal carcinogenic dose of methylcholanthrene.

Journal of pharmaceutical sciences

Effect of chronic oral administration of sodium cobaltinitrite and sodium nitrite on the minimal carcinogenic dose50 of methylcholanthrene in albino mice.

Paper

Effect of chronic oral administration of sodium cobaltinitrite and sodium nitrite on the minimal carcinogenic dose50 of methylcholanthrene in albino mice.

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Citations