Paper
Effect of cobalt chloride and sodium cobaltinitrite on the growth of established epithelial tumors induced by methylcholanthrene.
Published Mar 1, 1971 · Gerald P. O'Hara, David E. Mann, R. Gautieri
Journal of pharmaceutical sciences
6
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Abstract
Previous investigations showed that when cobaltous chloride or sodium cobaltinitrite is administered in conjunction with the topical application of the carcinogen, methylcholanthrene, the tumorigenic response is significantly decreased. The experimental design of this study involved the administration of each cobalt compound, following completion of the minimal carcinogenic dose50 (MCD50) regimen of methylcholanthrene when tumorigenesis was firmly established, to ascertain whether these agents could retard the growth of formed tumors in addition to inhibiting those during the period of tumorigenesis. It was demonstrated that cobaltous chloride and sodium cobaltinitrite have no influence on the growth of established epithelial tumors induced by methylcholanthrene and that the antitumorigenic capacity of these compounds is restricted solely to the incipient stages of cancerization.
Cobalt chloride and sodium cobaltinitrite do not affect the growth of established epithelial tumors induced by methylcholanthrene, and their antitumorigenic capacity is limited to the early stages of cancerization.
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