The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline.

doi:10.1016/S0027-5107(02)00150-1

Paper

DOI: 10.1016/S0027-5107(02)00150-1

The effect of deuterium and fluorine substitution upon the mutagenicity of N-hydroxy-2,6-dimethylaniline.

Published Sep 30, 2002 · M. Matilde Marques, G. Gamboa da Costa, L. R. Blankenship

Mutation research

UNKNOWN SJR score

Citations

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

N-hydroxy-4-fluoro-2,6-dimethylaniline reduces mutagenicity by about 90% in Salmonella typhimurium TA100 and 50% in Salmonella typhimurium TA98, while multiple adducts contribute to base substitution mutations.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

DOI: 10.1016/j.chemosphere.2020.126530

Characterization of N-(2,6-dimethylphenyl)hydroxylamine adducts of 2'-deoxyguanosine under weakly basic conditions.

N-(2,6-dimethylphenyl)hydroxylamine adducts of 2'-deoxyguanosine under weakly basic conditions are more stable, leading to greater potential for multiple DNA reactions.

2020·1citation·T. Matsui et al.·Chemosphere

Chemosphere

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METABOLIC ACTIVATION OF 2,6-DIMETHYLANILINE: MUTATIONAL SPECIFICITY IN THE GPT GENE OF AS52 CELLS

2,6-DMA exhibits mutagenicity at the gpt gene, mediated through hydroxylamine and aminophenol metabolites, contributing to its potential bladder carcinogenic effects in vivo.

2018·1citation·S. Moon et al.·Asian Journal of Pharmaceutical and Clinical Research

Asian Journal of Pharmaceutical and Clinical Research

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Novel Series of Dihydropyridinone P2X7 Receptor Antagonists.

A novel class of potent P2X7 inhibitors has been identified, suitable for evaluating the role of P2X7 in inflammatory, immune, neurologic, or musculoskeletal disorders.

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Journal of medicinal chemistry

DOI: 10.1016/j.yrtph.2011.08.010

Further investigations into the genotoxicity of 2,6-xylidine and one of its key metabolites.

2,6-xylidine's genotoxicity in vitro remains unclear, as it is impossible to detect mutagenic effects using various metabolic conditions or acetyltransferase-overexpressing strains of bacteria.

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Regulatory toxicology and pharmacology : RTP

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Influence of structural and functional modifications of selected genotoxic carcinogens on metabolism and mutagenicity – a review

Structural and functional modifications of genotoxic carcinogens influence their metabolism and mutagenic potential, aiding in screening and prioritizing chemicals for further testing.

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