Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.

doi:10.1016/J.EJPHAR.2005.10.016

Paper

Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.

Published Dec 19, 2005 · C. I. Araiza-Saldaña, G. Reyes‐García, D. Bermúdez-Ocaña

European journal of pharmacology

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32

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Sildenafil's intrathecal antinociceptive effect in non-diabetic rats involves activation of NO-cyclic GMP-PKG-K+ channels, but diabetes leads to dysfunction in NO and large-conductance Ca2+-activated K+ channels, potentially benefiting diabetes-

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.

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References

The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system

Small and intermediate conductance calcium-activated potassium channels are expressed in the rat sensory nervous system, with SK1, SK2, and IK1 preferentially localized to nociceptive neurone subpopulations.

Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice

Disfunction of the spinal nitric oxide/cGMP pathway may contribute to vincristine-induced painful neuropathy in mice.

Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib.

Lumracoxib activates NO-cyclic GMP-K(+) channels and the intrathecal serotonergic system to produce local and intrathecal antinociception, but not opioid receptors at peripheral or spinal sites.

Analysis of the mechanism underlying the peripheral antinociceptive action of sildenafil in the formalin test.

Sildenafil's local peripheral antinociceptive effect is mediated by activation of the cyclic GMP-PKG-K+ channel pathway, which can be blocked by various inhibitors.

The effects of intraspinal L-NOARG or SIN-1 on the control by descending pathways of incisional pain in rats.

Intraspinal L-NOARG or low doses of SIN-1 reduce incisional pain without affecting descending pain control pathways, while electrical stimulation of the dorsal raphe or anterior pretectal nuclei can enhance or overcome these effects.

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