Effect of estradiol benzoate and clomiphene on tyrosine hydroxylase activity and on luteinizing hormone and prolactin levels in ovariectomized rats.

doi:10.1016/0024-3205(81)90024-2

Paper

Effect of estradiol benzoate and clomiphene on tyrosine hydroxylase activity and on luteinizing hormone and prolactin levels in ovariectomized rats.

Published Aug 17, 1981 · H. Tobías, L. Carr, J. Voogt

Life sciences

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19

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0

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Estradiol benzoate and clomiphene together reduce tyrosine hydroxylase activity and increase luteinizing hormone levels in ovariectomized rats, with clomiphene acting as an estrogen antagonist.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effect of estradiol benzoate and clomiphene on tyrosine hydroxylase activity and on luteinizing hormone and prolactin levels in ovariectomized rats.

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References

Catecholamine synthesizing enzymes in the hypothalamus during the estrous cycle

Decreased dopaminergic neuron activity in the medial basal hypothalamus may precipitate the LH surge during proestrus, while increased dopamine--hydroxylase activity may also play a role.

Prolactin in cerebrospinal fluid: A probable site of prolactin autoregulation

Increasing prolactin concentrations in cerebrospinal fluid suppresses endogenous prolactin secretion and increases dopaminergic activity in the median eminence, suggesting autoregulation of prolactin secretion.

Studies on dopamine turnover in ovariectomized or hypo-physectomized female rats. effects of 17β-estradiol benzoate, ethynodioldiacetate and ovine prolactin

Dopamine neurons play a role in controlling prolactin and luteinizing hormone secretion, with tubero-infundibular DA neurons mediating central inhibitory feedback actions of prolactin and gonadal steroids.

Changes in catecholamine content in discrete brain nuclei during the estrous cycle of the rat

Catecholamine activity in discrete brain areas during the rat estrous cycle may influence ovulation and mating behavior.

The effect of castration, thyroidectomy and haloperidol upon the turnover rates of dopamine and norepinephrine and the kinetic properties of tyrosine hydroxylase in discrete hypothalamic nuclei of the male rat

Castration, haloperidol, and thyroidectomy increase dopaminergic terminal activity in the hypothalamus, with these effects occurring independently of changes in prolactin levels.

Citations

Female infertility

Female factors are the primary cause of subfertility in 70% of cases, with male factors accounting for 30% of the problem.

Region-specific changes of tyrosine hydroxylase-immunoreactivity by estrogen treatment in female rat hypothalamus

Estrogen treatment affects tyrosine hydroxylase-immunoreactivity in the female rat hypothalamus, modulating thyrosine production in a region-specific manner.

Estradiol and Progesterone Modulation of Norepinephrine Neurotransmission: Implications for the Regulation of Female Reproductive Behavior

Estradiol and progesterone modulate norepinephrine neurotransmission, affecting female reproductive behavior and ovulation timing in rodents.

Developmental regulation of tyrosine hydroxylase in the mediobasal hypothalamus.

Estradiol does not play a role in developmental regulation of tyrosine hydroxylase in the mediobasal hypothalamus, but depolarizing signals do.

Tyrosine hydroxylase in the stalk-median eminence and posterior pituitary is inactivated only during the plateau phase of the preovulatory prolactin surge.

Tyrosine hydroxylase in the stalk-median eminence and posterior pituitary is transiently inactivated during the plateau phase of the preovulatory prolactin surge, suggesting a nondopaminergic mechanism.