The effect of pyrazole on ethylene glycol toxicity and metabolism in the rat.

doi:10.1016/S0041-008X(78)80030-1

Paper

DOI: 10.1016/S0041-008X(78)80030-1

The effect of pyrazole on ethylene glycol toxicity and metabolism in the rat.

Published 1978 · Janet Y. Chou, K. E. Richardson

Toxicology and applied pharmacology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

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Pyrazole reduces ethylene glycol toxicity in rats by increasing ethylene glycol excretion and decreasing glycolate excretion, suggesting glycolate is the specific toxic agent in acute ethylene glycol poisoning.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Ethylene glycol poisoning can be treated with ethanol and hemodialysis, leading to complete recovery in a 40-year-old man after 3 weeks of treatment.

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Citations

DOI: 10.1016/j.toxlet.2017.06.009

A toxicological review of the ethylene glycol series: Commonalities and differences in toxicity and modes of action.

Ethylene glycols pose no health risk due to their intended use patterns, with no genotoxic or carcinogenic properties, and no embryotoxicity in humans at environmentally relevant doses.

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DOI: 10.1016/j.cbi.2014.12.040

Contribution of liver alcohol dehydrogenase to metabolism of alcohols in rats.

Liver alcohol dehydrogenase (ADH) plays a major role in the metabolism of alcohols in rats, but its activity is not solely rate-limiting.

2015·36citations·B. Plapp et al.·Chemico-biological interactions

Chemico-biological interactions

DOI: 10.1111/j.1476-4431.2011.00638.x

4-Methylpyrazole as a treatment in naturally occurring ethylene glycol intoxication in cats.

4-Methylpyrazole (Fomepizole) is a safe and effective treatment for naturally occurring ethylene glycol toxicity in cats, with increased HCO3 levels observed after IV use.

2011·11citations·Kelly M Tart et al.·Journal of veterinary emergency and critical care

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Ethylene glycol has been linked to acute, subacute, and chronic health effects, and adequate data is needed to determine exposure levels that pose a significant risk to human health.

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Antidotes for Alcohol and Glycol Toxicity: Translating Mechanisms Into Treatments

4methylpyrazole (4MP) shows potential as an antidote for toxic alcohol poisonings, particularly by methanol and ethylene glycol (EG).

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Safety and efficacy of high-dose fomepizole compared with ethanol as therapy for ethylene glycol intoxication in cats.

High-dose fomepizole is safe for cats, prevents fatal acute renal failure, and is more effective than ethanol treatment for ethylene glycol intoxication.

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Are calcium oxalate crystals involved in the mechanism of acute renal failure in ethylene glycol poisoning?

Calcium oxalate crystals accumulate in kidney tissue, leading to acute renal failure in ethylene glycol poisoning.

2009·98citations·K. McMartin·Clinical Toxicology

Clinical Toxicology

DOI: 10.1111/J.0954-6820.1982.TB03161.X

Studies on Ethylene Glycol Poisoning

Prompt hemodialysis is recommended in ethylene glycol poisoning to supplement alkali and ethanol treatment, as it effectively inhibits ethylene glycol metabolism.

2009·21citations·D. Jacobsen et al.·Acta Medica Scandinavica

Acta Medica Scandinavica