Paper
Effect of heptanol and ethanol on excitation wave propagation in a neonatal rat ventricular myocyte monolayer.
Published Sep 1, 2018 · A. Podgurskaya, V. Tsvelaya, S. Frolova
Toxicology in vitro : an international journal published in association with BIBRA
Q2 SJR score
6
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Heptanol significantly slows down excitation wave propagation in cardiac tissue, while ethanol slightly influences conduction velocities at clinically relevant concentrations.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
α2 Subunit–Containing GABAA Receptor Subtypes Are Upregulated and Contribute to Alcohol-Induced Functional Plasticity in the Rat Hippocampus
Alcohol intoxication and chronic intermittent alcohol exposure increase hippocampal 42 subtypes, potentially contributing to increased alcohol consumption and dependence in rats and humans.
2017·17citations·A. K. Lindemeyer et al.·Molecular Pharmacology
Molecular Pharmacology
Addictive drugs, arrhythmias, and cardiac inward rectifiers
Addictions like alcohol and nicotine may have proarrhythmic effects, highlighting the need for more data on their proarrhythmic potential.
2016·18citations·M. Bébarová et al.·Europace
Europace
Effect of ethanol and acetaldehyde at clinically relevant concentrations on atrial inward rectifier potassium current IK1: separate and combined effect.
Ethanol and acetaldehyde both affect atrial IK1 at clinically relevant concentrations, but their combined effect does not significantly differ from ethanol alone.
2016·15citations·Z. Hořáková et al.·Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Islands of spatially discordant APD alternans underlie arrhythmogenesis by promoting electrotonic dyssynchrony in models of fibrotic rat ventricular myocardium
Myocardial fibrosis and dynamic electrical instabilities together increase the incidence and complexity of reentrant arrhythmias, with higher myofibroblast densities leading to more complex arrhythmias.
2016·26citations·R. Majumder et al.·Scientific Reports
Scientific Reports
Atrial Anti-Arrhythmic Effects of Heptanol in Langendorff-Perfused Mouse Hearts
Heptanol has anti-arrhythmic effects in atrial mouse hearts, increasing effective refractory period and preventing atrial tachy-arrhythmias, while not altering ventricular arrhythmogenicity or these parameters.
2016·43citations·G. Tse et al.·PLoS ONE
PLoS ONE
Mechanisms of cardiac arrhythmias
Cardiac arrhythmias are primarily caused by disruptions in the orderly pattern of the propagating cardiac excitation wave, with recent advances in understanding their mechanisms.
2015·130citations·G. Tse·Journal of Arrhythmia
Journal of Arrhythmia
[Effect of ethanol and its metabolites on acetylcholine-sensitive K(+) channel Kir3.1 protein expression of neonatal rat primary atrial cardiomyocytes].
Acute ethanol and acetaldehyde treatment significantly upregulate the protein expression of acetylcholine-sensitive K(+) channel Kir3.1, potentially contributing to arrhythmia caused by acute alcoholic intoxication.
2015·8citations·Yuanyuan Zhao et al.·Zhonghua xin xue guan bing za zhi
Zhonghua xin xue guan bing za zhi
Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes.
Ethanol has a dual effect on inward rectifier potassium current I(K1) in rat ventricular myocytes, potentially contributing to cardiac electrophysiological changes and arrhythmias.
2014·30citations·M. Bébarová et al.·Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
Citations
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Indoxyl sulfate reduces Ito,f density and related proteins in CKD rats by activating ROS/MAPK and NF-B signaling pathways, increasing the susceptibility to arrhythmia in chronic kidney disease.
2022·12citations·Jing Yang et al.·JCI Insight
JCI Insight
Cyclophosphamide arrhythmogenicitytesting using human-induced pluripotent stem cell-derived cardiomyocytes
Cyclophosphamide, an anticancer drug, can decrease maximum capture rate and conductivity area in human-induced pluripotent stem cell-derived cardiomyocytes, potentially causing arrhythmic effects in vivo.
2021·13citations·A. Podgurskaya et al.·Scientific Reports
Scientific Reports
Muscular Thin Films for Label-Free Mapping of Excitation Propagation in Cardiac Tissue
Muscular thin films (MTFs) can effectively and non-toxicly map excitation waves in cardiomyocyte cell cultures, potentially benefiting cardiac tissue engineering and lab-on-a-chip systems.
2020·4citations·V. A. Balashov et al.·Annals of Biomedical Engineering
Annals of Biomedical Engineering
Myofibroblast modulation of cardiac myocyte structure and function
Myofibroblasts, but not fibroblasts, alter cardiac myocyte structure and function, potentially playing an active role in arrhythmogenic substrate after cardiac remodelling.
2019·42citations·C. Nagaraju et al.·Scientific Reports
Scientific Reports
Mechanisms of U-Shaped Association between Alcohol Intake and the Risk of Sudden Cardiac Death
Moderate alcohol consumption may protect against sudden cardiac death by improving conduction at narrow ventricular pathways and preventing re-entry formation, while higher doses may increase the risk.
2019·0citations·Karagueuzian Hs et al.·Journal of Heart Health
Journal of Heart Health