The effect of beta-phenylethylamine on central and peripheral monoamine-containing neurons.

doi:10.1016/0014-2999(67)90088-X

Paper

DOI: 10.1016/0014-2999(67)90088-X

The effect of beta-phenylethylamine on central and peripheral monoamine-containing neurons.

Published Dec 1, 1967 · K. Fuxe, H. Grobecker, J. Jonsson

European journal of pharmacology

Q1 SJR score

133

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Phenylethylamine has an amphetamine-like action, decreasing amine content in noradrenaline and dopamine-containing nerve terminals in the brain and peripheral adrenergic nerve terminals in rats.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Effect of directly and indirectly acting sympathomimetic amines on adrenergic transmitter granules.

Sympathetic amines affect noradrenaline release and reuptake in splenic nerve granules differently than their effects on overall uptake in perfused organs.

1968·38citations·U. V. von Euler et al.·Acta physiologica Scandinavica

Acta physiologica Scandinavica

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Effect of ß-phenylethylamine on content and subcellular distribution of norepinephrine in rat heart and brain

Phenylethylamine causes a depletion of norepinephrine in rat hearts and brains, with preferential release from the particulate fraction, reaching 15% of control value after two hours.

1966·36citations·J. Jonsson et al.·Life Sciences

Life Sciences

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Inhibition of amine uptake in tubero‐infundibular dopamine neurones and in catecholamine cell bodies of the area postrema

Tuberoinfundibular dopamine neurones and catecholamine cell bodies in the area postrema have an amine uptake-concentration mechanism unaffected by reserpine treatment, suggesting a potential role for these neurones in regulating mood.

1966·17citations·K. Fuxe et al.·Journal of Pharmacy and Pharmacology

Journal of Pharmacy and Pharmacology

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Biochemical and histochemical studies on the effects of imipramine-like drugs and (+)-amphetamine on central and peripheral catecholamine neurons.

Desipramine and protriptyline block the reserpine-resistant amine-concentrating mechanism in central and peripheral noradrenaline fibers, while (+)-amphetamine causes release of amines from extragranular locations within both noradrenaline and dopamine fibers.

1966·422citations·A. Carlsson et al.·Acta physiologica Scandinavica

Acta physiologica Scandinavica

DOI: 10.1016/0024-3205(66)90177-9

Effects of tyrosine hydroxylase inhibition on the amine levels of central monoamine neurons

Tyrosine hydroxylase inhibition causes catecholamine levels in rat brain and spinal cord to disappear almost completely in 24 hours, with recovery occurring after 48 hours.

1966·199citations·N. Andén et al.·Life Sciences

Life Sciences

Citations

DOI: 10.1016/j.neubiorev.2021.09.020

Trace amine-associated receptor 1 (TAAR1): Potential application in mood disorders: A systematic review

TAAR1 agonist SEP-363856 shows promise in improving cognitive and reward function in mood disorders, with potential applications in treating depression, anxiety, and addiction.

2021·21citations·Yazen Alnefeesi et al.·Neuroscience & Biobehavioral Reviews

Neuroscience & Biobehavioral Reviews

DOI: 10.1016/J.JIEC.2021.06.002

Selective hydrogenation of benzonitrile and its homologues to primary amines over platinum

Platinum on carbon catalysts (Pt/C) provide the best results for selective hydrogenation of benzonitriles to primary amines, with high yields and selectivities to primary amines.

2021·10citations·Krisztina Lévay et al.·Journal of Industrial and Engineering Chemistry

Journal of Industrial and Engineering Chemistry

DOI: 10.1124/pr.117.015305

Trace Amines and Their Receptors

Trace amines and their receptors play diverse roles in various physiological processes and have potential therapeutic applications for various diseases.

2018·283citations·R. Gainetdinov et al.·Pharmacological Reviews

Pharmacological Reviews

DOI:

Identification and in vivo Characterization of a Potential TAAR1 Antagonist

Compound 22 potentiates amphetamine and cocaine-mediated locomotor activity, but its biological target remains unknown.

2017·0citations·V. Lam

DOI: 10.1016/J.PHARMTHERA.2007.06.007

Trace amine-associated receptor 1-Family archetype or iconoclast?

TAAR1 is a GPCR that activates trace amines, but its in vivo pharmacology and physiology remain unclear, making it a potential family archetype or iconoclast.

2007·191citations·D. Grandy·Pharmacology & therapeutics

Pharmacology & therapeutics