Paper
Effect of Turkesterone on the Pancreas Histology and Function in Diabetic Rats
Published Jan 1, 2020 · DOI · L. S. Kuchkarova, Rokhimova So, Syrov Vn
International journal of current research and review
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Abstract
It is known diabetes can lead to potential complications such as encephalopathy, heart disease, hypertension, tachycardia, kidney damage, stroke, nerve damage, visual impairment, seizures, and other pathologies.1,2 So, there is a growing need for multifunctional drugs to treat diabetes and improve its adverse metabolic effects. In recent years, special attention has been given to the treatment with phytoecdysteroids, as these substances have shown to have a wide range of positive effects on different metabolic pathways. Phytoecdisteroids are involved in the regulation of carbohydrates3.and protein metabolism.4,5 It has been found their antioxidant6,7, anti-inflammatory8, antiparasitic8, immunomodulatory10, anabolic4 and cholesterol-lowering7 properties. Another important property of phytochysteroids is a reduction in blood glucose level. The blood glucose level had been halved, when alloxan-induced diabetic rats were given complex of phytoecdisteroids isolated from Ajuga iva.7,11 The hypoglycemic property was demonstrated in ecdysone, 2-dexoxyecdysone isolated from the Silenepraemixta as well as in 2-deoxyecdisterone and integristeron isolated from Rhaponticum carthamoides.3 Ecdysterone, 22-acetylceiasterone and turkesterone isolated from Ajugaturkestanica also decrease glucose level in intact rats.3
Turkesterone shows potential in treating diabetes by reducing blood glucose levels and improving pancreas function in diabetic rats.
- PopulationOlder adults (50-71 years)
- Sample size24
- MethodsObservational
- OutcomesBody Mass Index projections
- ResultsSocial networks mitigate obesity in older groups.
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