Effectiveness of tamsulosin hydrochloride and its mechanism in improving nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia

doi:10.1002/nau.20872

Paper

Effectiveness of tamsulosin hydrochloride and its mechanism in improving nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia

Published Sep 29, 2009 · Masaki Yoshida, A. Inadome, K. Masunaga

Neurourology and Urodynamics

Q2 SJR score

22

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2

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Abstract

To evaluate the action mechanism of α1‐receptor blockers in improving nocturia, we have studied effectiveness of tamsulosin hydrochloride (TAM) in the patients with nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH).

Non-RCT

Study Snapshot

Tamsulosin hydrochloride effectively improves nocturia in patients with lower urinary tract symptoms/benign prostatic hyperplasia, demonstrating a 1-receptor blocker action mechanism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effectiveness of tamsulosin hydrochloride and its mechanism in improving nocturia associated with lower urinary tract symptoms/benign prostatic hyperplasia

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References

[Nocturia and benign prostatic hyperplasia].

No statistically significant improvement in nocturia symptoms occurred after prostate surgery, but age and prostatic size significantly correlate with nocturia.

The relationship between objective frequency-volume chart data and the I-PSS in men with lower urinary tract symptoms.

The International Prostate Symptom Score (I-PSS) and frequency-volume chart data have weak associations in assessing lower urinary tract symptoms in men, with differences potentially explained by perceived quality of life.

Effect of tamsulosin hydrochloride on lower urinary tract symptoms and quality of life in patients with benign prostatic hyperplasia. Evaluation using bother score.

Tamsulosin hydrochloride significantly improves lower urinary tract symptoms and quality of life in patients with benign prostatic hyperplasia, with nocturia being the most predictably affected symptom.

Crossover comparison study on the therapeutic effects of tamsulosin hydrochloride and naftopidil in lower urinary tract symptoms associated with benign prostatic hyperplasia.

Tamsulosin hydrochloride is more effective than naftopidil for treating lower urinary tract symptoms associated with benign prostatic hyperplasia.

Improvement in bladder storage function by tamsulosin depends on suppression of C-fiber urethral afferent activity in rats.

Tamsulosin improves bladder storage function by suppressing C-fiber urethral afferent activity in rats, suggesting a potential mechanism for improving bladder storage symptoms.

Citations