Paper
Neuropharmacological effects of 1,4-butanediol and related congeners compared with those of gamma-hydroxybutyrate and gamma-butyrolactone
Published Nov 1, 1966 · H. Sprince, J. Josephs, C. Wilpizeski
Life Sciences
Q1 SJR score
49
Citations
3
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Non-RCT
Animal StudyStudy Snapshot
1,4-butanediol exhibits neuropharmacological effects similar to those of GHB and GBL, with some minor variations, and pyruvate may prevent or reverse anesthetic effects induced by these compounds.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
SODIUM 4-HYDROXYBUTYRATE.
Sodium 4-hydroxybutyrate has low toxicity, hypnotic activity, potentiating anesthetics and neuroplegics, and facilitating hypothermia, with potential applications in anaesthesiology, obstetrics, psychiatry, and internal medicine.
1964·246citations·H. Laborit·International journal of neuropharmacology
International journal of neuropharmacology
Differential Estimation of Gamma-butyrolactone and Gamma-hydroxybutyric Acid in Rat Blood and Brain
This study developed a sensitive and specific gas chromatographic technique for estimating concentrations of anesthetic adjuvants -butyrolactone and -hydroxybutyrate in rat blood and brain, revealing that anesthesia onset and duration correlate with brain concentrations rather than lactone concentrations
1964·92citations·N. J. Giarman et al.·Science
Science
Gamma Hydroxybutyrate and Gamma Butyrolactone: Concentration in Rat Tissues during Anesthesia
Gamma-hydroxybutyric acid and gamma-butyrolactone induce sleep in rats, with the concentration of the lactone in the brain being related to the induced sleep.
1964·43citations·S. Bessman et al.·Science
Science
Gamma-Hydroxybutyrate, a Normal Brain Metabolite
Gamma-hydroxybutyrate (GHB) is a normal brain metabolism that plays a role in the Krebs cycle and contributes to neurotransmitter production.
1963·210citations·S. Bessman et al.·Nature
Nature
Metabolism of acetoin. I. The formation and utilization of acetoin and butane-2:3-diol in the decerebrated cat.
Acetoin and butane-2:3-diol injections in cats lead to variations in blood levels and a rapid disappearance of these compounds from the blood, with no significant increase in glycogen formation.
1954·12citations·J. Dawson et al.·The Biochemical journal
The Biochemical journal
The Therapy of Experimental Influenza in Mice with Antibiotic Lactones and Related Compounds *
Antibiotic lactones show potential in treating experimental influenza in mice, potentially offering a new approach to combat viral infections.
1947·26citations·Rubin Ba et al.·The Yale Journal of Biology and Medicine
The Yale Journal of Biology and Medicine
GAMMA-HYDROXYBUTYRATE IN MAMMALIAN BRAIN. REVERSIBLE OXIDATION BY LACTIC DEHYDROGENASE.
LACTIC DEHYDROGENASE plays a crucial role in reducing succinic semialdehyde in mammalian brain, contributing to y-hydroxybutyrate metabolism and cellular energy production.
1964·89citations·W. Fishbein et al.·The Journal of biological chemistry
The Journal of biological chemistry
Citations
Fatal intoxication with 1,4‐butanediol: Case report and comprehensive review of the literature
Fatal intoxications with 1,4-butanediol are rare due to rapid conversion to GHB and non-specific symptoms after ingestion.
2023·1citation·Victoria Fischer et al.·Journal of Forensic Sciences
Journal of Forensic Sciences
Clinical Pharmacology of 1,4‐Butanediol and Gamma‐hydroxybutyrate After Oral 1,4‐Butanediol Administration to Healthy Volunteers
Oral 1,4-butanediol is quickly absorbed and cleared, with significant inter-individual variability in metabolism, potentially related to variants in ADH-IB, but no significant clinical effects were observed.
2007·63citations·D. Thai et al.·Clinical Pharmacology & Therapeutics
Clinical Pharmacology & Therapeutics
Chromatographic methods in clinical chemistry and toxicology
High-performance liquid chromatography is a reliable and cost-effective method for analyzing active ingredients in herbal nutritional supplements, detecting alcohol abuse, and detecting congenital disorders of glycolysis.
2007·5citations·R. Bertholf et al.
4‐Methylpyrazole Decreases 1,4‐Butanediol Toxicity by Blocking Its in Vivo Biotransformation to γ‐Hydroxybutyric Acid
4methylpyrazole (4MP) effectively reduces 1,4-butanediol toxicity by inhibiting its biotransformation to hydroxybutyric acid in a murine model of overdose.
2004·13citations·L. Quang et al.·Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences
Pretreatment of CD-1 mice with 4-methylpyrazole blocks toxicity from the gamma-hydroxybutyrate precursor, 1,4-butanediol.
Pretreatment with 4-methylpyrazole significantly decreases the toxicity of 1,4-butanediol in CD-1 mice, potentially by inhibiting its biotransformation to GHB.
2002·29citations·L. Quang et al.·Life sciences
Life sciences