Paper
Effects of 3,4,5,6-tetrahydroxyxanthone on myocardial ischemia-reperfusion injury in isolated rat hearts
Published Jan 1, 2005 · Hu Chang-ping
Chinese Journal of Clinical Pharmacology and Therapeutics
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Abstract
AIM: To study the protective effects and mechanisms of 3,4,5,6-tetrahydroxyxanthone on myocardial ischemia-reperfusion injury in isolated rat hearts. METHODS: Ischemia-reperfusion injury was induced by 30 min of global ischemia and 30 min of reperfusion in isolated rat hearts. Heart rate, coronary flow (CF), left ventricular pressure (LVP), and the first derivative (+dp/dt_(max)) were recorded. The activity of creatine kinase in coronary effluent and tumor necrosis factor-alpha (TNF-α) content in myocardial tissues were measured. RESULTS: 3,4,5,6-tetrahydroxyxanthone (30, 100 or 300 (μmol·L~(-1))) caused a significant improvement of cardiac function and a decrease in the release of creatine kinase in coronary effluent as well as the level of TNF-α in myocardial tissues. CONCLUSION:3,4,5,6-tetrahydroxyxanthone possesses a protective effect on myocardial ischemia-reperfusion injury, and the effects may be related to inhibition of TNF-α production.
3,4,5,6-tetrahydroxyxanthone protects against myocardial ischemia-reperfusion injury by improving cardiac function and reducing TNF- production in isolated rat hearts.
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