The cactus alkaloid 3,4-dimethoxyphenethylamine and its naturally occurring N-methylated homologs inhibited the deamination of tyramine and tryptamine by rat brain monoamine oxidase. In contrast, the beta-hydroxylated derivatives of this series failed to inhibit the action of monoamine oxidase on both tyramine and tryptamine.

3,4-dimethoxyphenethylamine and its N-methylated homologs inhibit monoamine oxidase, while beta-hydroxylated derivatives do not.

Paper

Effects of 3,4-dimethoxyphenethylamine derivatives on monoamine oxidase.

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