Paper
Effects of 3,4-dimethoxyphenethylamine derivatives on monoamine oxidase.
Published Jul 1, 1977 · W. Keller, G. Ferguson
Journal of pharmaceutical sciences
Q2 SJR score
6
Citations
0
Influential Citations
Abstract
The cactus alkaloid 3,4-dimethoxyphenethylamine and its naturally occurring N-methylated homologs inhibited the deamination of tyramine and tryptamine by rat brain monoamine oxidase. In contrast, the beta-hydroxylated derivatives of this series failed to inhibit the action of monoamine oxidase on both tyramine and tryptamine.
In Vitro StudyStudy Snapshot
3,4-dimethoxyphenethylamine and its N-methylated homologs inhibit monoamine oxidase, while beta-hydroxylated derivatives do not.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Selectivity of 4-methoxyphenethylamine derivatives as inhibitors of monoamine oxidase.
4-methoxyphenethylamine and its N-methylated homologs selectively inhibit monoamine oxidase-catalyzed deamination of both tyramine and tryptamine, potentially benefiting neurotransmitter function.
1976·4citations·W. Keller et al.·Journal of pharmaceutical sciences
Journal of pharmaceutical sciences
Monoamine oxidase inhibiting activity of a series of (+/-)-4-methoxy-beta-hydroxyphenethylamines.
(+/-)-4-methoxy-beta-hydroxyphenethylamines show partial prevention of reserpine-induced hypothermia in mice and inhibit monoamine oxidase, with the most active member being the secondary amine.
1975·4citations·G. Ferguson et al.·Journal of pharmaceutical sciences
Journal of pharmaceutical sciences
Cactaceae Alkaloids XVIII: Two New Alkaloids from Coryphantha Calipensis H. Bravo
Two new alkaloids, ()--O-methylnormacromerine and ()--O-methylmacromerine, were isolated from the Mexican cactus Coryphantha calipensis H. Bravo.
1974·12citations·J. Bruhn et al.·Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences
Properties of monoamine oxidase in nerve endings from two bovine brain areas
Monoamine oxidase activity is higher in the hypothalamus compared to the thalamus, with two interacting sites for serotonin and norepinephrine metabolism in intact mitochondria.
1974·19citations·B. Tabakoff et al.·Brain Research
Brain Research
Cactus alkaloids. XV. -Phenethylamine derivatives from Coryphantha macromris var. runyonii.
This study identifies 11 -phenethylamine derivatives in Coryphantha macromris var. runyonii, providing new insights into the occurrence of alkaloids in cacti.
1973·27citations·W. Keller et al.·Journal of pharmaceutical sciences
Journal of pharmaceutical sciences
yote Alkaloids: Identification in the Mexican ictus Pelecyphora aselliformis Ehrenberg
Mescaline, anhalidine, pellotine, and other alkaloids have been identified in the Mexican "peyote" cactus Pelecyphora aselliformis tenberg, making it the first non-Lophophora cactus to contain these compounds.
1972·14citations·J. Neal et al.·Science
Science
Cactus alkaloids VIII: Isolation ofn-methyl-3,4-dimethoxy-β-phenethylamine fromariocarpus fissuratus var.fissuratus
N-methyl-3,4-dimethoxy--phenethylamine HCl, a new alkaloid found in Ariocarpus fissuratus var. fissuratus, is a potential medicinal compound with potential therapeutic applications.
1970·10citations·D. Norquist et al.·Journal of Pharmaceutical Sciences
Journal of Pharmaceutical Sciences
Cactaceae alkaloids. VII. Alkaloids of Echinocereus merkeri.
Echinocereus merkeri contains a new class of alkaloids, including N, N-dimethyl-3,4-dimethoxyphenethylamine, 3,4-dimethoxyphenethylamine, 3-methoxytyramine, and hor
1969·20citations·S. Agurell et al.·Journal of pharmaceutical sciences
Journal of pharmaceutical sciences
Citations
Altered States of Consciousness During Ceremonial San Pedro Use
Ceremonial San Pedro use leads to strong spiritual experiences, ego-dissolution, and mystical experiences, with low disembodiment, anxiety, impaired control, and higher physical distress and grief in challenging experiences.
2022·1citation·Arne Bohn et al.·The International Journal for the Psychology of Religion
The International Journal for the Psychology of Religion
The Alkaloids from Lophophora diffusa and Other "False Peyotes".
Lophophora diffusa and other "false peyotes" share similarities with "true" peyote, Lophophora williamsii, and their alkaloids have potential pharmacological effects.
2021·9citations·Camilla B Chan et al.·Journal of natural products
Journal of natural products
Crystal structure, spectroscopic, quantum chemical and Hirshfeld surface analysis of [2–(3, 4–Dimethoxy–phenyl)–ethyl]–(4–nitro–benzylidene)–amine: A combined experimental and theoretical study
The crystal structure of Schiff's name compound, C 17H 18N 2O4, reveals non-covalent interactions and a potential therapeutic use in treating inflammatory diseases.
2021·1citation·C. Arunagiri et al.·Chemical Data Collections
Chemical Data Collections
Isotope effects in the tyrosinase catalysed hydroxylation of l-tyrosine methyl derivatives
O-methyl-l-tyrosine is an uncompetitive inhibitor of tyrosinase, affecting the enzyme's kinetic and solvent deuterium isotope effects in methylated derivatives of l-tyrosine.
2018·1citation·M. Pająk et al.·Isotopes in Environmental and Health Studies
Isotopes in Environmental and Health Studies
[14C]normacromerine fate in the rat.
[14C] normacromerine is primarily eliminated through urine in rats, with minimal feces and 14CO2 expiration, suggesting potential hallucinogenic potential.
1984·1citation·P. Ferguson et al.·Journal of pharmaceutical sciences
Journal of pharmaceutical sciences