Effects of 5,5-diphenylhydantoin and related carbamates and hydroxylamines on nucleic acid and protein synthesis of proliferating human lymphocytes.

doi:10.1016/0041-008X(75)90241-0

Paper

Effects of 5,5-diphenylhydantoin and related carbamates and hydroxylamines on nucleic acid and protein synthesis of proliferating human lymphocytes.

Published Jul 1, 1975 · A. MacKinney, R. Vyas

Toxicology and applied pharmacology

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4

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Abstract

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In Vitro Study

Study Snapshot

5,5-diphenylhydantoin and related compounds inhibit DNA and protein synthesis in proliferating human lymphocytes, with the N3 position playing a central role in metabolic reactions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Effects of 5,5-diphenylhydantoin and related carbamates and hydroxylamines on nucleic acid and protein synthesis of proliferating human lymphocytes.

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References

The assay of diphenylhydantoin effects on growing human lymphocytes.

Diphenylhydantoin inhibits thymidine incorporation in human lymphocytes at suprapharmacologic concentrations, possibly due to membrane transport, but the mechanism of its inhibition at pharmacologic concentrations remains unknown.

Diphenylhydantoin-Induced Inhibition of Nucleic Acid Synthesis in Cultured Human Lymphocytes

Diphenylhydantoin inhibits DNA synthesis in phytohemagglutinin-stimulated human lymphocytes, with RNA and protein synthesis also inhibited at higher concentrations.

Immunological Abnormalities and Hydantoins

Hydantoins may influence humoral immunity in patients with epilepsy, potentially affecting humoral immunity differently than cellular immunity.

Diphenylhydantoin effects on human lymphocytes in vitro and in vivo. An hypothesis to explain some drug reactions.

Diphenylhydantoin may cause serious reactions and may negatively impact lymphocyte numbers, potentially contributing to lymphoma and autoimmune phenomena.

Depression of immunological function in patients treated with phenytoin sodium (sodium diphenylhydantoin).

Phenytoin sodium treatment can cause depression of cellular or humoral immunity in some patients, with similar effects observed in lymphoma patients.

Citations

Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests.

Diphenylhydantoin (DPH) is devoid of mutagenic properties in in vitro short-term tests, as negative results were observed in all tested systems.

Phenytoin Influence on Human Lymphocyte Mitogen Response: A Prospective Study of Epileptic and Nonepileptic Patients

Phenytoin does not suppress lymphocyte responsiveness to mitogens in epileptic patients, as previously reported, and may slightly increase it in those with decreased serum IgA levels.

Toxic effects of antiepileptic drugs on immunoglobulin gene expression.

Toxic levels of antiepileptic drugs, such as phenytoin and carbamazepine, can significantly reduce or eliminate lambda light chain secretion in murine myeloma cells, potentially affecting long-term B cell function.

Birth defects in epilepsy: role of phenytoin and convulsion

Maternal phenytoin therapy and convulsive seizure episodes during embryogenesis are more significant factors in causing birth malformations than epilepsy itself.