Concentration-dependent effects of anticonvulsant enaminone methyl 4-(4′-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate on neuronal excitability in vitro

doi:10.1016/j.neuroscience.2006.03.021

Paper

Concentration-dependent effects of anticonvulsant enaminone methyl 4-(4′-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate on neuronal excitability in vitro

Published Dec 31, 2006 · K. V. Ananthalakshmi, I. Edafiogho, S. Kombian

Neuroscience

Q2 SJR score

24

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Methyl 4-(4′-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate suppresses action potential firing at therapeutically relevant concentrations by suppressing tetrodotoxin-sensitive sodium currents, while induc

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Concentration-dependent effects of anticonvulsant enaminone methyl 4-(4′-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate on neuronal excitability in vitro

Sign up to use Study Snapshot

References

Anticonvulsant enaminones depress excitatory synaptic transmission in the rat brain by enhancing extracellular GABA levels

Anticonvulsant enaminones cause synaptic depression by enhancing extracellular GABA levels, potentially through the inhibition of either NMDA or non-NMDA receptors.

Voltage-gated ion channels

Voltage-dependent ion channels play a crucial role in nerve impulse generation and cell homeostasis, with advances in molecular biology, spectroscopy, and structural techniques revealing their main features and structural changes.

Recent insights into the structure and mechanism of the sodium pump.

The sodium pump pumps sodium ions through a membrane-spanning protein, Na-K-ATPase, to maintain cell function.

The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions

Increased Persistent Sodium Currents in Rat Entorhinal Cortex Layer V Neurons in a Post–Status Epilepticus Model of Temporal Lobe Epilepsy

Post-status epilepticus in rats leads to increased persistent sodium currents in entorhinal cortex layer V neurons, potentially contributing to temporal lobe epilepsy.

Citations

Synthesis of Novel Pyrazolyl and Isoxazolyl 3-(Furan-2-yl)-5-Methyl-1-(4-Nitrophenyl)-1H-Pyrazol-4-yl Derivatives via Regioselectivity of the 1,3-Dipolar Cycloaddition

This study demonstrates the synthesis of novel pyrazolyl and isoxazolyl derivatives using 1,3-dipolar cycloaddition, resulting in pyrazolopyridazines and isoxazolopyridazines.

Novel Bipyrazole and Pyrazolopyridazinone derivatives via Regioselective Cycloaddition Reaction of Nitrilimines to Enaminone: Synthesis and Structural Elucidation

Novel bipyrazole and pyrazolopyridazinone derivatives were synthesized and confirmed by spectral data, elemental analyses, and single-crystal X-ray diffraction.

Anti-Inflammatory Properties of the Enaminone E121 in the Dextran Sulfate Sodium (DSS) Colitis Model

E121 shows significant anti-inflammatory properties in the pathogenesis of IBD, reducing colitis severity in mice through modulated immune cell functions.

Evaluation of the antinociceptive activities of enaminone compounds on the formalin and hot plate tests in mice

E139 has antinociceptive activity in both formalin and hot plate tests, with its effects dependent on GABA receptors.

Allosteric Modulation of GABAA Receptors by an Anilino Enaminone in an Olfactory Center of the Mouse Brain

KRS-5Me-4-OCF3 shows potential as an anticonvulsant agent by inhibiting mitral cell activity and acting as a positive allosteric modulator of GABAA receptors in the mouse brain.