Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1.

doi:10.1016/s0022-3565(24)29681-6

Paper

DOI: 10.1016/s0022-3565(24)29681-6

Effects of benzyl isothiocyanate on rat and human cytochromes P450: identification of metabolites formed by P450 2B1.

Published Jan 1, 2001 · T. Goosen, Danielle E. Mills, P. Hollenberg

The Journal of pharmacology and experimental therapeutics

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Abstract

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In Vitro Study

Study Snapshot

Benzyl isothiocyanate effectively inactivates rat and human cytochromes P450s, potentially contributing to its chemopreventative action against carcinogenesis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Benzyl Isothiocyanate and Resveratrol Synergistically Alleviate Dextran Sulfate Sodium-Induced Colitis in Mice

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2020·1citation·Yang Suo et al.·Neuron

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Benzyl isothiocyanate fumigation inhibits growth, membrane integrity and mycotoxin production in Alternaria alternata

Benzyl isothiocyanate (BITC) effectively inhibits Alternaria alternata growth, membrane integrity, and mycotoxin production in pear black spot, suggesting membrane-targeted mechanisms.

2020·18citations·Tiaolan Wang et al.·RSC Advances

RSC Advances

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Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel

The study presents high-resolution cryo-EM structures of TRPA1 and its covalent agonists JT010 and BITC, providing insights into electrophile sensing and providing a platform for future drug development targeting TRPA1.

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Neuron

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Urea-based soluble epoxide hydrolase inhibitors are present in several plants in the Brassicales order, including maca roots, which may have potential therapeutic applications for reducing pain and inflammation.

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PLoS ONE