Multiple effects of ethane dimethanesulfonate on the epididymis of adult rats.

doi:10.1016/0041-008X(90)90189-2

Paper

Multiple effects of ethane dimethanesulfonate on the epididymis of adult rats.

Published Sep 1, 1990 · G. Klinefelter, J. Laskey, N. Roberts

Toxicology and applied pharmacology

Q2 SJR score

37

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Ethane dimethanesulfonate (EDS) has distinct effects on the epididymis of adult rats, causing sperm granulomas, alterations in sperm membrane proteins, and decreased sperm motility and velocity, unrelated to circulating testosterone or testicular

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Multiple effects of ethane dimethanesulfonate on the epididymis of adult rats.

References

Gonadotrophin Levels in Male Rats Following Impairment of Leydig Cell Function by Ethylene Dimethanesulphonate

Ethylene dimethanesulphonate impairs leydig cell function in male rats, leading to a rapid rise in serum LH and a biphasic increase in serum FSH, but no change in prolactin levels.

Transepithelial movement of ^3H-androgen in seminiferous and epididymal tubules : A study using in vivo micropuncture and in vivo microperifusion

The factors controlling the proluminal movement of 3H-androgens in the rat testis and epididymis are fundamentally different, with restricted movement in the seminiferous tubule and increased transport in the epididymal tubule.

Ornithine decarboxylase activity as a marker of androgen and antiandrogen action in the rat epididymis.

Endogenous androgens are essential for maintaining ornithine decarboxylase activity in the epididymis, and antiandrogen flutamide's potency is significantly lowered by increased epididymal androgens.

Androgen binding protein in serum, testis and epididymis following treatment with the Leydig cell cytotoxic agent, ethylene dimethanesulphonate.

Ethylene dimethanesulphonate treatment in adult male rats leads to increased serum and tissue ABP levels, but decreased androgen secretion in testes and epididymides.

Androgen‐Regulated Epididymal Secretory Proteins Associated with Post‐testicular Sperm Development a

The precise physiological functions of androgen-regulated epididymal secretory proteins remain unclear, but glycoproteins D and E may be associated with surface receptors responsible for gamete recognition.

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