Paper
Effects of ethane dimethanesulfonate on the structure of adult male rat adrenal cortex.
Published Jun 1, 1997 · DOI · B. Plećaš, A. Glavaski, V. Savic
Pharmacological research
6
Citations
0
Influential Citations
Abstract
The influence of ethane dimethanesulfonate (EDS), a specific toxicant for Leydig cells, on the morphometric characteristic of adult male rat adrenal cortex was examined on day 15 after administration. As expected, the dose of 75 mg kg-1 of EDS produced drastic reduction in serum testosterone levels followed by a decrease in testis and seminal vesicle weight. However, a considerable drop (over 50%) in adrenal weight was also found. Stereological analysis of the adrenal cortex, performed under light microscope, revealed atrophy of all adrenocortical zones. The changes were most prominent in the inner zones. Thus, in the zona fasciculata the number of parenchymal cells was markedly decreased. In the zona reticularis a layer consisting mostly of atrophic parenchymal cells was localised at the border between zona reticularis and zona fasciculata. The remaining small number of cortical cells in this zone displayed a notable hypertrophy. It is concluded that EDS at a dose that destroys Leydig cells has a strong deleterious effect on steroidogenic cells of adult male rat adrenal cortex.
Ethane dimethanesulfonate (EDS) at a dose that destroys Leydig cells has a strong deleterious effect on steroidogenic cells in adult male rat adrenal cortex, causing atrophy and significant weight loss.
Full text analysis coming soon...