Effects of hexadecylphosphocholine on membrane phospholipid metabolism in human tumour cells.

doi:10.1016/0959-8049(95)00350-9

Paper

Effects of hexadecylphosphocholine on membrane phospholipid metabolism in human tumour cells.

Published Nov 1, 1995 · D. Berkovic, U. Grunwald, W. Menzel

European journal of cancer

Q1 SJR score

35

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Hexadecylphosphocholine inhibits membrane uptake of inositol and choline in sensitive human tumor cells, potentially affecting cellular phosphatidylcholine metabolism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Effects of hexadecylphosphocholine on membrane phospholipid metabolism in human tumour cells.

Sign up to use Study Snapshot

References

Antagonism of phorbol-ester-stimulated phosphatidylcholine biosynthesis by the phospholipid analogue hexadecylphosphocholine.

Hexadecylphosphocholine (HePC) antagonizes phorbol-ester-stimulated phosphatidylcholine biosynthesis in MDCK and HeLa cells, suggesting choline uptake plays a role in regulating PtdCho biosynthesis.

Inhibition of cellular transport systems by alkyl phospholipid analogs in HL-60 human leukemia cells.

Alkyl phospholipids selectively kill neoplastic cells by inhibiting cellular transport of essential nutrients, such as choline, amino acids, fatty acids, and glucose, in sensitive HL-60 leukemia cells.

Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.

Cytotoxic ether lipid analogues selectively inhibit phosphatidylinositol phospholipase C, potentially contributing to their growth inhibitory activity.

Hexadecylphosphocholine inhibits translocation of CTP:choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.

Hexadecylphosphocholine directly inhibits phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells, suggesting a direct inhibitory effect on CTP:choline-phosphate cytidylyltransferase translocation.

The phospholipid analogue hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis in Madin—Darby canine kidney cells

Hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis in Madin-Darby canine kidney cells, reducing phosphatidylcholine content and increasing phosphatidylethanolamine content.

Citations