Comparative effects of indole and aminoacetonitrile derivatives on dimethylnitrosamine-demethylase and aryl hydrocarbon hydroxylase activities.

doi:10.1016/0304-3835(80)90120-2

Paper

Comparative effects of indole and aminoacetonitrile derivatives on dimethylnitrosamine-demethylase and aryl hydrocarbon hydroxylase activities.

Published Apr 1, 1980 · J. Arcos, S. Myers, B. Neuburger

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18

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Abstract

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In Vitro Study

Study Snapshot

Indole compounds and aminoacetonitrile derivatives show complex effects on carcinogen metabolism, with L-tryptophan and 3-indolylmethanol doubling enzyme activity, while -3-indolylethanol has no effect.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Comparative effects of indole and aminoacetonitrile derivatives on dimethylnitrosamine-demethylase and aryl hydrocarbon hydroxylase activities.

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References

Induction of Dimethylnitrosamine-demethylase by Polar Solvents

Polar solvents like acetone, dioxane, tetrahydrofuran, di-methylsulfoxide, trioctanoin, and Tween 80 can induce hepatic dimethylnitrosamine-demethylase I activity, potentially playing a role in tobacco

The effect of L-tryptophan and certain other amino acids on liver nitrosodimethylamine demethylase activity.

L-tryptophan increases liver nitrosodimethylamine-demethylase activity, while cysteine has the opposite effect, and other amino acids show no effect.

Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by naturally occurring indoles.

Indole-3-carbinol and 3,3'-diindolylmethane from cruciferous vegetables can inhibit polycyclic aromatic hydrocarbon-induced neoplasia in animals, potentially benefiting our understanding of environmental carcinogens.

Dietary constituents altering the responses to chemical carcinogens.

Dietary components like cruciferous vegetables and antioxidants may help inhibit the neoplastic response to chemical carcinogens.

Dimethylnitrosamine-demethylase: absence of increased enzyme catabolism and multiplicity of effector sites in repression. Hemoprotein involvement.

Pretreatment with 3-methylcholanthrene does not increase enzyme breakdown but decreases de novo synthesis, with multiple effector sites involved in repression.

Aryl hydrocarbon hydroxylase induction in rat tissues by naturally occurring indoles of cruciferous plants.

Indoles in cruciferous vegetables, such as Brussels sprouts, cabbage, and cauliflower, can increase aryl hydrocarbon hydroxylase activity in rats, potentially benefiting health.

Inhibition of dimethylnitrosamine-induced strand breakage in rat liver DNA by aminoacetonitrile.

Aminoacetonitrile effectively prevents single strand breaks in rat liver DNA caused by dimethylnitrosamine, suggesting its dependence on nitrosamine metabolism to an active methylating agent.

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