Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines.

doi:10.1016/s0021-9258(18)46861-5

Paper

Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines.

Published Nov 11, 1994 · M. Park, E. Wolff, Y. B. Lee

The Journal of biological chemistry

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155

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5

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Abstract

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In Vitro Study

Highly Cited

Study Snapshot

Inhibitors of deoxyhypusine synthase, such as N1-guanyl-1,7-diaminoheptane, effectively inhibit cell growth by inhibiting hypusine synthesis without affecting polyamine metabolism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines.

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