Effects of Nitrapyrin [2-Chloro-6-(Trichloromethyl) Pyridine] on the Obligate Methanotroph Methylosinus trichosporium OB3b

doi:10.1128/aem.47.2.258-262.1984

Paper

Effects of Nitrapyrin [2-Chloro-6-(Trichloromethyl) Pyridine] on the Obligate Methanotroph Methylosinus trichosporium OB3b

Published Feb 1, 1984 · E. Topp, R. Knowles

Applied and Environmental Microbiology

Q1 SJR score

24

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0

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Abstract

Nitrapyrin inhibited growth, CH4 oxidation, and NH4+ oxidation, but not the oxidation of CH3OH, HCHO, or HCOONa, by Methylosinus trichosporium OB3b, suggesting that nitrapyrin acts against the methane monooxygenase enzyme system. The inhibition of CH4 oxidation could be reversed by repeated washing of nitrapyrin-inhibited cells, indicating that its effect is bacteriostatic. The addition of Cu2+ did not release the inhibition. Methane oxidation was also inhibited by 6-chloro-2-picoline. These data suggest that the mode of action of nitrapyrin on M. trichosporium is different from that on chemoautotrophic NH4+ oxidizers or methanogens.

In Vitro Study

Study Snapshot

Nitrapyrin inhibits growth, CH4 oxidation, and NH4+ oxidation in Methylosinus trichosporium OB3b, suggesting a different mode of action than chemoautotrophic NH4+ oxidizers or methanogens.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Effects of Nitrapyrin [2-Chloro-6-(Trichloromethyl) Pyridine] on the Obligate Methanotroph Methylosinus trichosporium OB3b

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