Paper
Effects of different doses of lipitor on blood lipid and safety of senile patients with coronary heart diseases
Published 2007 · W. Da
Journal of the Fourth Military Medical University
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Abstract
AIM:To evaluate the efficacy and safty of lipitor at different doses for the treatment of senile patients with coronary heart disease.METHODS:Seventy-two patients(≥75 years old) with coronary heart diseases were randomized into therapy group and control group.In therapy group(n=35),lipitor 30 mg/d was orally administered before sleeping,and in control group(n=37) lipitor 10 mg/d was given in the same way.The total treatment lasted 15 weeks.The dosage was risen to 30 mg/d in control group for those who did not reach the control serum level after 5-week treatment.RESULTS:After 15-week treatment,the levels of total cholesterol(TC) and low density lipoprotein cholesterol(LDL-C) in therapy group decreased remarkedly as compared with control group(P0.01).The incidence of non-lethal myocardial infarction,unstable angina pectoris,cardiac death,and vascular reaonstruction in therapy group also declined(P0.05 vs control group).No more side effects of lipitor were seen after it had risen to 30 mg/d for 15 weeks(P0.05).CONCLUSION:Lipotor 30 mg/d is superior to lipotor 10 mg/d in reduction of TC,LDL-C,TG and increase of high-densily lipoprotein cholesterol(HDL-C).The side effects of lipitor 30 mg/d were mild and similar to 10 mg/d.30 mg/d lipitor is efficacy and safe for the senile patients with coronary heart diseases.
RCTLipitor 30 mg/d is more effective and safe for senile patients with coronary heart disease than 10 mg/d, reducing total cholesterol and LDL-C levels while increasing HDL-C levels.
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