The effects of p-hydroxypropiophenone on the thyroid gland of experimental animals.

doi:10.1210/JCEM-11-9-973

Paper

The effects of p-hydroxypropiophenone on the thyroid gland of experimental animals.

Published Sep 1, 1951 · W. L. Money, V. Lucas, J. Fager

The Journal of clinical endocrinology and metabolism

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12

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0

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Abstract

RECENT reports from France (1) indicate that p-hydroxypropioj phenone shows a marked ability to alleviate the signs and symptoms of thyrotoxicosis. Perrault has postulated that the beneficial effects of this drug are due to an inhibition of the production of the thyroid-stimulating hormone. Although confirmatory evidence of this observation is lacking, the results and conclusions which have been reported make a careful investigation of the physiologic action of this compound essential. In the course of our studies on the growth and function of the thyroid gland we have investigated the effect of p-hydroxypropiophenone on thyroid function in experimental animals. This report is the result of these studies. MATERIALS AND METHODS One hundred and twenty mature male rats of the Sprague-Dawley strain were used. In addition, 40 three-day-old chicks1 were also used. The experiments were set up in the following manner: Experiment I. Four groups (10 animals per group) of male rats were given a low-iodine diet (2). ...

Non-RCT

Animal Study

Study Snapshot

P-hydroxypropiophenone shows a marked ability to alleviate thyrotoxicosis symptoms in experimental animals, possibly due to inhibition of thyroid-stimulating hormone production.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

The effects of p-hydroxypropiophenone on the thyroid gland of experimental animals.

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References

Citations

Zur Wirkung des Vitamin A auf endokrine Systeme

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P‐HYDROXYPROPIOPHENONE FOR ADVANCED BREAST CANCER: A PRELIMINARY REPORT

A responsive mother-child relationship, based on individuality and responsiveness, is crucial for infant growth and physical health, and helps children learn about the world outside themselves.

Parahydroxypropiophenone effects on rat thyroid, adrenal, and pituitary.

Parahydroxypropiophenone does not inhibit thyrotropic hormone secretion in rats, but it does cause distinct changes in the thyroid, adrenal, and pituitary glands.

Compounds interfering with ovum implantation and development. II. Synthetic estrogens and antiestrogens.

ORF-3858 is the only synthetic estrogen and antiestrogen that effectively prevents pregnancy in macaque monkeys without causing teratogenicity.

Chemistry and physiology of the thyroid-stimulating hormone.

Thyroid-stimulating hormone (TSH) is a complex, anterior pituitary hormone with a direct correlation to thyroid gland activity, but its precise chemistry and physiology remain unclear.