A Simple and Efficient New Approach to the Total Synthesis of (±)-4-Amino-3-(4-Chlorophenyl)-Butyric Acid (BACLOFEN)

doi:10.1080/00397919708004109

Paper

DOI: 10.1080/00397919708004109

A Simple and Efficient New Approach to the Total Synthesis of (±)-4-Amino-3-(4-Chlorophenyl)-Butyric Acid (BACLOFEN)

Published Jul 1, 1997 · F. Coelho, M. D. Azevedo, R. Boschiero

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Abstract

Abstract Based on the utilization of a [2+2] cycloaddition reaction between dichloroketene and an appropriated olefin as a key step, we describe a new and simple four step approach to the total synthesis of (±)-4-amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN), a selective GABAB agonist used as antispastic agent

Study Snapshot

This new four-step approach enables the total synthesis of ()-4-amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN), a selective GABAB agonist used as antispastic agent, with improved efficiency and lower costs.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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