Paper
An Efficient Synthetic Approach Towards 4-Cyano-3- (Methylthio)-5-Oxo-2H-Pyrazole-1(5H)-Carbothioamide And Its Derivatives As Potent Antimicrobial Agents.
Published Apr 24, 2015 · Journals Invention, P. Sambhaji
0
Citations
0
Influential Citations
Abstract
Synthesis of novel heterocyclic 4-cyano -3-(methylthio)-5-oxo-2H-pyrazole-1(5H)carbothioamide (3) was prepared by condensing ethyl-2-cyano-3,3-bis (methylthio)acrylate (1) with thiosemicarbazide (2) in DMF and catalytic amount of potassium carbonate. Compound (3) has methylthio group at third position, which is replaced by different nucleophiles such as substituted anilines| phenols| hetryl amines| compounds containing active methylene group to afford 3-substituted derivatives of compound (3). All the newly synthesized compounds were screened for their antimicrobial activity.
This study presents an efficient synthetic approach for 4-cyano-3-(methylthio)-5-oxo-2H-pyrazole-1(5H)-carbothioamide and its derivatives, which show potential as potent antimicrobial agents.
Full text analysis coming soon...