Nielsen and Zhang et al. show that well-established, Notch4-induced brain arteriovenous malformations are normalized, following deletion of the Notch signaling mediator, Rbpj. Upon complete regression, virtually no AVM relapses in adults, even when the causal factor is reintroduced.

Deleting the Rbpj protein in mice effectively normalizes Notch4-induced brain arteriovenous malformations, with minimal relapses in adults.

Paper

Endothelial Rbpj deletion normalizes Notch4-induced brain arteriovenous malformation in mice

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