We attempted to epimerize 1-deoxynojirimycin to produce 1-deoxymannojirimycin, a potent mannosidase inhibitor which blocks conversion of high-mannose to complex saccharide on N-asparagine linked glucan biosynthesis. The data reported describes the microbial conversion of 1-deoxynojirimycin to the manno-form and its glycosidase inhibitory activity

Microbial conversion of 1-deoxynojirimycin to 1-deoxymannojirimycin produces a potent mannosidase inhibitor with potential applications in glucan biosynthesis inhibition.

Paper

Microbial epimerization of 1-deoxynojirimycin to 1-deoxymannojirimycin.

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