Paper
Ethyl glyoxylate N-tosylhydrazone as sulfonyl-transfer reagent in base-catalyzed sulfa-Michael reactions.
Published Jan 3, 2014 · Maitane Fernández, U. Uria, Lucía Orbe
The Journal of organic chemistry
Q2 SJR score
27
Citations
0
Influential Citations
Abstract
Ethyl glyoxylate N-tosylhydrazone has been identified as an excellent sulfonyl anion surrogate in the DBU-catalyzed conjugate addition reaction with enones and enals for the synthesis of functionalized sulfones. The reaction proceeds under base-catalyzed conditions and provides a direct access to γ-keto- and γ-hydroxy sulfones in a simple and reliable way through a sulfa-Michael reaction that proceeds with high yield and chemoselectivity.
Study Snapshot
Ethyl glyoxylate N-tosylhydrazone is an excellent sulfonyl anion surrogate for synthesis of functionalized sulfones with high yield and chemoselectivity in base-catalyzed sulfa-M
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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