Evaluation of 4-phenylamino-substituted naphthalene-1,2-diones as tubulin polymerization inhibitors.

doi:10.1016/j.bmcl.2018.07.047

Paper

Evaluation of 4-phenylamino-substituted naphthalene-1,2-diones as tubulin polymerization inhibitors.

Published Oct 1, 2018 · Honghao Yang, B. An, Xingshu Li

Bioorganic & medicinal chemistry letters

Q2 SJR score

6

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Abstract

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In Vitro Study

Study Snapshot

4-phenylamino-substituted naphthalene-1,2-dione derivatives show potent antiproliferative activities against human cancer cells, induced by mitochondrial depolarization and tubulin polymerization inhibition.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Evaluation of 4-phenylamino-substituted naphthalene-1,2-diones as tubulin polymerization inhibitors.

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