Silver sulfadiazine is a new topical antimicrobial agent that is used effectively to prevent and treat sepsis in patients with second- and third-degree burns. Because of its low toxicity, relative freedom from complications, and wide spectrum of antimicrobial activity, silver sulfadiazine represents an advance in the pharmacologic management of the burned patient. ( JAMA 230:1184-1185, 1974)

Silver sulfadiazine effectively prevents and treats sepsis in patients with second- and third-degree burns, offering low toxicity, relative freedom from complications, and a wide spectrum of antimicrobial activity.

Paper

Evaluation of a new topical agent for burn therapy. Silver sulfadiazine (silvadene).

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