Evaluation of antidepressant activity of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a β-substituted phenylethylamine in mice

doi:10.1016/j.euroneuro.2010.12.003

Paper

Evaluation of antidepressant activity of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a β-substituted phenylethylamine in mice

Published Sep 1, 2011 · A. Dhir, S. Malik, S. Kessar

European Neuropsychopharmacology

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Abstract

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Non-RCT

Animal Study

Study Snapshot

1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-cyclohexanol shows antidepressant-like activity in animal models of depression by modulating neurotransmitter levels in the brain.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Evaluation of antidepressant activity of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a β-substituted phenylethylamine in mice

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References

Citations

Molecular Mechanisms and Applications of a Reserpine-Induced Rodent Model

Reserpine, a compound from Rauwolfia serpentina, effectively induces depression in rodent models, providing valuable insights for drug discovery and understanding pain-depression dyads.

Effect of Hydroalcoholic extract of Mimosa Pudica Linn. with Imipramine and Fluoxetine on Reserpine-induced Behavioural Despair in Rats

Combining hydroalcoholic extract of Mimosa pudica Linn. with fluoxetine and imipramine in subeffective doses can potentially exert antidepressant-like effects through modulation of brain serotonergic system and MAO inhibition.

Antidepressant-like effect of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a putative trace amine receptor ligand involves l-arginine–nitric oxide–cyclic guanosine monophosphate pathway

The antidepressant-like effect of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol involves the L-arginine-nitric oxide-cyclic guanosine mono

Regioselective Synthesis and Antibacterial Studies of α,β-Unsaturated Ketone Substituted Cyclohexanols via Tandem Michael Addition-Aldol Addition-Cyclization Sequence under Solvent-Free Conditions

This green, one-pot strategy for synthesis of novel antibacterial compounds offers operational simplicity, short reaction time, high yields, and environmental benefits, while avoiding tedious workup.