Preliminary evaluation of antioxidant activity of some 1-(phenoxyethyl)-piperazine derivatives.

Paper

Preliminary evaluation of antioxidant activity of some 1-(phenoxyethyl)-piperazine derivatives.

Published 2006 · A. Pietrzycka, M. Stepniewski, A. Waszkielewicz

Acta poloniae pharmaceutica

Q3 SJR score

27

Citations

0

Influential Citations

Semantic Scholar

Abstract

The antioxidant properties of appropriate 1-(phenoxyethyl)-piperazine derivatives possessing significant hypotensive activity in normotensive rats were measured in human venous blood samples, in vitro. Ferric reducing ability of plasma (FRAP) was measured in plasma, superoxide dismutase (SOD) and catalase (CAT) activities were determined in red blood cell hemolysates. Antioxidant profile of 1-(phenoxyethyl)-piperazine derivatives was compared to Trolox and Resveratrol. The compounds were investigated in concentrations from 10(-8) to 10(-4) mol x L(-1). The most promising compounds were 1-[(4-methyl)- and 1-[(2,6-dimethyl)-phenoxyethyl]-piperazine derivatives [1, 2] which increased SOD activity and total antioxidant capacity (TAC). An addition of chlorine atom to methyl-phenoxy moiety decreased antioxidant properties.

In Vitro Study

Study Snapshot

1-(phenoxyethyl)-piperazine derivatives show promising antioxidant properties, with 1-[(4-methyl)- and 1-[(2,6-dimethyl)-phenoxyethyl]-piperazine derivatives showing increased SOD activity and total antioxidant capacity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Preliminary evaluation of antioxidant activity of some 1-(phenoxyethyl)-piperazine derivatives.

References

Citations