Paper

Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group.

Published Sep 1, 2014 · C. Ballatore, Bryant C Gay, Longchuan Huang

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

Cyclopentane-1,2-dione may be a useful carboxylic acid bio-isostere for drug design, as it shows potential as a potent thromboxane A2 prostanoid receptor antagonist with an IC50 value comparable to the parent carboxylic acid.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group.

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