Paper
Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group.
Published Sep 1, 2014 · C. Ballatore, Bryant C Gay, Longchuan Huang
Bioorganic & medicinal chemistry letters
Q2 SJR score
7
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Cyclopentane-1,2-dione may be a useful carboxylic acid bio-isostere for drug design, as it shows potential as a potent thromboxane A2 prostanoid receptor antagonist with an IC50 value comparable to the parent carboxylic acid.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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Oxetan-3-ol and thietan-3-ol show promise as potential bioisosteres of the carboxylic acid moiety, offering potential for new anti-inflammatory drugs and cyclooxygenase inhibitors.
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Electrostatic potentials and average electron densities of bioisosteres in methylsquarate and acetic acid.
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