Mechanistic evaluation of a novel cyclohexanone derivative's functionality against nociception and inflammation: an in-vitro, in-vivo and in-silico approach.

doi:10.1016/j.ejphar.2021.174091

Paper

Mechanistic evaluation of a novel cyclohexanone derivative's functionality against nociception and inflammation: an in-vitro, in-vivo and in-silico approach.

Published Apr 15, 2021 · Jawad Khan, G. Ali, U. Rashid

European journal of pharmacology

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24

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0

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Rigorous Journal

Study Snapshot

CHD shows potential anti-nociceptive and anti-inflammatory properties, likely mediated through GABAergic and opioidergic interactions, COX-2 and 5-LOX enzyme inhibition, and reduced pro-inflammatory cytokine expression.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Mechanistic evaluation of a novel cyclohexanone derivative's functionality against nociception and inflammation: an in-vitro, in-vivo and in-silico approach.

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