Paper
Evaluation of the role of imidazolidinone motif of antineoplas-tic 4-phenyl-1-arylsulfonylimidazolidinones using 4-phenyl-2-aryl-sulfonyloxazolines
Published Dec 1, 2001 · Sang-hun Jung, Kyung-Lae Park, Hui-Soon Lee
Archives of Pharmacal Research
Q1 SJR score
17
Citations
0
Influential Citations
Abstract
To evaluate the role of imidazolidinone moiety of potential anticancer 4-phenyl-1 -arylsulfonylimidazolidinones1 for their cytotoxicity, conformationally similar 4-phenyl-2-arylsulfonylaminooxazolines2 were synthesized and compared their cytotoxicities with those of the corresponding1. Compounds2 showed much reduced activity compared to N-arylsulfonylimidazolidinones1. This result might indicate that the imidazolidinone ring of1 have the other roles for the activity as an essential structural motif in addition to conformational contribution.
In Vitro StudyStudy Snapshot
The imidazolidinone ring of potential anticancer 4-phenyl-1-arylsulfonylimidazolidinones plays a crucial role in their cytotoxicity, with conformational contribution being less important than essential structural roles.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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