Paper
Exploring the 7-oxo-thiazolo[5,4-d]pyrimidine core for the design of new human adenosine A3 receptor antagonists. Synthesis, molecular modeling studies and pharmacological evaluation.
Published May 26, 2015 · F. Varano, D. Catarzi, L. Squarcialupi
European journal of medicinal chemistry
Q2 SJR score
23
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
A new series of 5-methyl-thiazolo[5,4-d]pyrimidine-7-ones showed good to high affinity and selectivity for human adenosine A3 receptor, with 2-(4-chlorophenyl)-5-methyl-thiazolo[5,4-d]
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Citations
A simple, facile and greener route to thiazolo[3,2-c]pyrimidinones in semi-aqueous medium and their antibacterial properties
This study presents a simple, efficient, and greener method for synthesis of new 3-oxothiazolo[3,2-c]pyridimines in semi-aqueous medium, with some showing bacteriostatic effects against S. aureus and S. epidermidis bacteria.
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Reaction of chloroethynylphosphonates with 1,3-diethyl 2-(acylamino)propanedioates
Chloroethynylphosphonates react with 1,3-diethyl 2-(acylamino)propanedioates to produce 2-substituted 5-(dialkoxyphosphoryl)methylidene-2-oxazoline-4,4-dicarboxylate
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Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression
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Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents.
Novel compounds with high affinity, selectivity, and potency can be developed as potential antitumor agents by targeting CD73 and A2A adenosine receptors.
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Transformation of Racemic Azlactones into Enantioenriched Dihydropyrroles and Lactones Enabled by Hydrogen-Bond Organocatalysis
This study demonstrates the first organocatalytic Mannich reaction with propargyl-substituted azlactones, enabling the synthesis of complex molecules with high enantioselectivity.
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