4-phenyl-2-butanone is a important medium to synthesize medicine for diminish inflammation and codeine.The ethyl ethanate is synthesized with ethanol and acetic acid as materials and strong acid as catalyst(such as sulfuric acid,chloric acid,p-methyl-benzene sulfonic acid and strong acidity ion exchange resin etc.).Ethyl acetoacetate ia compounded by Claisen's condensation with a series of acid,alkali,nucleophilic addition and remove reaction.And the synthesis of 4-phenyl-3-methyl ethanate-2-butanone is by ethyl acetoacetate with benzyl chloride via substitution reaction.4-phenyl-2-butanone via 4-phenyl-3-methyl ethanate-2-butanone hydrolysis to decarboxylize.

4-phenyl-2-butanone is synthesized by using ethyl acetoacetate, benzyl chloride, and strong acid catalysts, and is used in medicine for diminishing inflammation and codeine production.

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Fabrication of 4-Phenyl-2-Butanone

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