A facile, scalable preparation of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carbonitriles

doi:10.1016/J.TETLET.2008.09.107

Paper

A facile, scalable preparation of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carbonitriles

Published Nov 24, 2008 · L. N. Tumey, Niala Bhagirath, Biqi Wu

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Abstract

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Study Snapshot

This study presents a new, scalable method for preparing 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carbonitriles from 2-aminothiophene-3-carboxylate esters, which can be easily transformed into key intermediates for

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

A facile, scalable preparation of 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carbonitriles

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References

2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCtheta.

2-alkenyl amides are potent and selective inhibitors of PKCtheta, with compound 8 showing excellent selectivity over various PKC isoforms.

Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles.

The optimized analog 29 has a 7.5 nM inhibitory concentration against PKC, with moderate activity against PKC.

Identification of 7-phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors.

7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles show potent inhibition of Src kinase activity when substituted with a thiophene ring.

A versatile and efficient synthesis of 3-aroyl-1,4-dihydroquinolin-4-ones

This study presents a versatile and efficient method for preparing 3-aroyl-4-quinolones using Michael-type addition and promoted cyclisation, yielding various quinolones.

Studies with enaminones: The reaction of enaminones with aminoheterocycles. A route to azolopyrimidines, azolopyridines and quinolines

Enaminones can be used to create azolopyrimidines, azolopyridines, and quinolines by reacting with aminoheterocycles, resulting in various enaminone derivatives.

Citations

An Eco‐friendly Synthesis and Biological Screening of Fused Heterocyclic Compounds Containing a Thiophene MoietyviaGewald Reaction

The study synthesized eco-friendly compounds with a thiophene moiety using microwave, ultrasonic, and ball-milling techniques, and evaluated their antibacterial and antifungal potentials.

Synthesis and Characterization of New 2-Methoxy-Thieno[2,3-d]pyrimidin-4(3H)-One

This study presents an efficient method for synthesizing 2-methoxy-thieno[2,3-d]pyrimidin-4(3H)-one (5) using an aza-Wittig reaction between iminophosphorane, 4-chlorophenyl isocyanine, and CH3OH

The Gewald multicomponent reaction

The Gewald reaction produces highly substituted 2-aminothiophene derivatives, useful in pharmaceutical industry as small molecular weight inhibitors.

Chapter 6.1: Six-membered ring systems: pyridine and benzo derivatives

Cyclocondensations and related polar cyclizations are efficient, practical, and environmentally friendly methods for synthesizing pyridines and their benzo derivatives, with potential applications in biological and material sciences.