A simple and efficient method was developped for the synthesis of 3-(5-amino-4-cyano-1H-imidazol-1-yl)-4-substituted benzoic acids 3. These compounds were isolated by intramolecular cyclisation of the corresponding 3-{[(Z)-2-amino-1,2-dicyano-vinyl]amino}methyleneaminobenzoic acids in the presence of base.

This method allows for the efficient synthesis of 5-amino-4-cyano-1H-imidazol-1-yl) benzoic acids with regioselective properties, offering potential applications in pharmaceutical and biotechnology industries.

Paper

A facile regioselective synthesis of (5-amino-4-cyano-1H-imidazol-1-yl) benzoic acids

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