Facile Synthesis of 3-Methyl-4-Arylmethylene-Isoxazol-5(4H)-Ones Catalysed by Sodium Silicate in an Aqueous Medium

doi:10.3184/174751911X13176501108975

Paper

Facile Synthesis of 3-Methyl-4-Arylmethylene-Isoxazol-5(4H)-Ones Catalysed by Sodium Silicate in an Aqueous Medium

Published Oct 1, 2011 · Qing Liu, R. Wu

Journal of Chemical Research

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38

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Abstract

Isoxazoles have significant hypoglycaemic, immunosuppressive, anti-inflammatory, and anti-bacterial activities. A convenient high yielding procedure for the one-pot synthesis of 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones by the condensation of ethyl acetoacetate, hydroxylamine hydrochloride and aromatic aldehydes in the presence of sodium silicate pentahydrate as an efficient catalyst in water at room temperature is described.

Study Snapshot

This one-pot method efficiently synthesizes 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones, a promising hypoglycemic, immunosuppressive, anti-inflammatory, and antibacterial agent, with high yields in water at room temperature.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Facile Synthesis of 3-Methyl-4-Arylmethylene-Isoxazol-5(4H)-Ones Catalysed by Sodium Silicate in an Aqueous Medium

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References

Citations

Waste to Wealth Catalyzed Synthesis of 3-methyl-4-(hetero)arylmethyleneisoxazole- 5(4H)-ones and pBR 322 DNA Cleavage Studies

WELFSA is an eco-friendly catalyst for the synthesis of pharmacologically significant 3-methyl-4-(hetero)arylmethyleneisoxazole-5(4H)-ones, with potential for use in pharmaceuticals.

An efficient, green and micellar catalyzed preparative-scale synthesis of 3,4-Disubstituted isoxazole-5(4H)-ones in the water

The micellar-catalyzed one-pot synthesis of 3,4-Disubstituted isoxazole-5(4H)-ones in water is efficient, green, and can be reused multiple times without significant loss of catalytic activity.

(Betaine: Citric Acid: H 2 O) a Natural Deep Eutectic Solvent (NaDES)-Mediated Efficient and Green Synthesis of 4-Benzylidene Isoxazol-5-one Derivatives

NaDES catalysts, made from Betaine and natural acids, enable efficient and green synthesis of 4-Benzylidene Isoxazol-5-one derivatives, with up to 98% yield and minimal use of toxic solvents.

Eucalyptol: An efficient, unexplored, green media for transition metal free synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives and isoxazolone derivatives

Eucalyptol is an eco-benign, green solvent for the synthesis of 2,3-dihydroquinazolin-4(1H)-one and isoxazolone derivatives without transition metal catalysts.

Introduction of [2,2'-Bipyridine]-1,1'-Diium Perchlorate as a Novel and Highly Efficient Dicationic Brönsted Acidic Organic Salt for the Synthesis of 3-Methyl-4-Arylmethylene Isoxazole-5(4H)-One Derivatives in Water

The novel pyridinium-based dicationic organic salt, [H2-BiPyr][ClO4]2, offers easy preparation, high yields, short reaction times, and reusability for the synthesis of 3-methyl-4-arylmethylene isoxazole-5(4H

Fruit Extract of Averrhoa bilimbi: A Green Neoteric Micellar Medium for Isoxazole and Biginelli-Like Synthesis

Averrhoa bilimbi extract (ABE) offers an eco-friendly, non-toxic alternative for isoxazol-5(4H)-one synthesis and Biginelli-like synthesis, with excellent yields and minimal waste.

Sustainable and green synthesis of 3-methyl-4-arylmethylene-isoxazole-5(4H)-one derivatives under mild conditions using a novel phosphoric acid-based molten salt as catalyst

This study developed a green, recyclable, and cost-effective method for synthesising bioactive 3-methyl-4-arylmethylene-isoxazole-5(4H)-one derivatives using pyrrolidinium dihydrogen phosphate as a catalyst.